Arthritis and Joint Replacement

Sjogren's Syndrome

Sjögren's syndrome is an autoimmune disease in which the body's immune system mistakenly attacks its own moisture producing glands. As a result, a person with this condition usually experiences dry eyes and a dry mouth. Sjögren's syndrome also may cause dryness of the skin or vagina, and rarely may affect other organs, such as the lungs, kidneys, gastrointestinal tract or nervous system. Patients also may suffer from joint pain or fatigue.

Affecting as many as four million Americans, Sjögren's syndrome is one of the most common of the autoimmune diseases. Nine out of 10 patients are women, and onset is typically in middle age. The cause of Sjögren's syndrome is unknown, although heredity, infection and hormones may be contributing factors.

Sjögren's syndrome can occur by itself, called primary Sjögren's syndrome. It also can occur with another rheumatic disease -- such as rheumatoid arthritis, systemic lupus, scleroderma and polymyositis-dermatomyositis -- called secondary Sjögren's syndrome.

Treatment for Sjögren's syndrome focuses on alleviating its symptoms, often with over-the-counter medications. These include non-steroidal anti-inflammatory drugs (NSAIDs), preservative-free artificial tears, artificial salivas, unscented skin lotions, saline nasal sprays and vaginal lubricants. Exercise can help lessen joint pain and build physical stamina.

For more information or to make an appointment, please call:
Rheumatology Clinic (415) 353-2497

Reviewed by health care specialists at UCSF Medical Center.
Last updated August 29, 2007